Matthew S. Davids, M.D., MMSc
Associate Professor of Medicine, Harvard Medical School
Director of Clinical Research, Division of Lymphoma, DFCI
Dr. Davids received his AB (artium baccalaureus) cum laude in Chemistry from Harvard College, his MD cum laude from Yale University School of Medicine, and his MMSc (Masters in Medical Sciences) degree from Harvard Medical School. He trained in internal medicine at New York Presbyterian Weill-Cornell Medical Center and Memorial Sloan Kettering Cancer Center in New York City before returning to his native Boston to complete his fellowship in hematology and oncology in the Dana-Farber/Brigham & Women's/Massachusetts General Hospital Program. He did his postdoctoral laboratory training in the Letai Lab under the mentorship of Dr. Anthony Letai, where he showed that decreased mitochondrial apoptotic priming underlies stroma-mediated treatment resistance in CLL and that priming may predict response to therapy in CLL.
In 2011, Dr. Davids joined the faculty of Harvard Medical School and Dana-Farber Cancer Institute, where he is now Associate Professor of Medicine, Director of Clinical Research in the Division of Lymphoma, and Associate Director of the CLL Center. He is a leading clinical investigator in the development of the Bcl-2 inhibitor venetoclax. He also pioneered the use of checkpoint blockade to treat patients with hematologic malignancies who relapse after allogeneic stem cell transplantation. He leads numerous investigator-initiated clinical trials of novel agent combination regimens for patients with CLL and NHL. On the laboratory side he leads a group that uses the BH3 profiling technique to study trial samples with a goal of predicting response to therapy and understanding resistance mechanisms. The lab works on a diverse array of areas that also include: the biology of CD47 blockade in hematologic malignancies, novel therapeutic combination strategies in T cell prolymphocytic leukemia, and elucidating novel functional mechanisms of venetoclax resistance.
In his spare time, Dr. Davids loves to spend time with his wife and two kids, cycle each year in the Pan-Mass Challenge, run, play squash, listen to a diverse array of music, and travel.